000			02945nam a22003615i 4500
001			81456
003			ES-MaUEC
005			20230202102928.0
007			cr nn 008mamaa
008			151209s2015 gw | s |||| 0|eng d
020			_a9783319199832
040			_aES-MaUEC
050		4	_aRC268.4 _b.C476 2015 EB
245	0	0	_aChromosomal Translocations and Genome Rearrangements in Cancer _cedited by Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts
250			_a1st ed. 2015.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (IX, 490 p.) 72 il., 69 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThis volume collates world expertsâ€{u0A6E}sights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations, and which launched a field in cancer genetics. Â{u04F5}bsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aCáncer _xAspectos genéticos _9273952 _0comprobar BNE19990911214 _2embne
700	1		_aRowley, Janet D. _eeditor literario _993894 _0Local
700	1		_aLe Beau, Michelle M. _eeditor literario _991431 _0Local
700	1		_aRabbitts, Terence H. _eeditor literario _993895 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-19983-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319199832
907			_a.b12900461 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b10-03-17 _cm _dz _ef _feng _ggw _h0
945			_aRC268.4 .C476 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11570088 _z06-04-17
999			_c81456 _d81456 _x1