000			03621nam a22003855i 4500
999			_c81445 _d81445
001			81445
003			ES-MaUEC
005			20230213132302.0
007			cr nn 008mamaa
008			150806s2015 gw | s |||| 0|eng d
020			_a9783319194974
024	7		_a10.1007/978-3-319-19497-4 _2doi
040			_aES-MaUEC _bspa
050		4	_aQH671 _b.P768 2015
245	1	0	_aProteases in Apoptosis : _bPathways, Protocols and Translational Advances _cedited by Kakoli Bose.
250			_a1st ed. 2015.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XV, 245 páginas) _b51 ilustraciones, 50 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aApoptosis: Pathways, Molecules and Beyond -- Caspases - key players in apoptosis -- Calpains and Granzymes: non-caspase proteases in cell death -- Cathepsins and HtrAs - multitasking proteases in programmed cell death -- Proteases in Apoptosis: Protocols and Methods -- Preclinical Animal Model and Non-invasive Imaging in Apoptosis.
520	3		_aThis book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeuticsÂ{u1CA5} recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research.
650		7	_aBioquímica clínica _2embne _9149316
650		7	_aApoptosis. _9157983 _2embne
650	2	7	_aCiencias biomédicas _2embne _9143729
700	1		_aBose, Kakoli _eeditor literario _993873 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-19497-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12900357 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aQH671 .P768 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11569979 _z06-04-17
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0