000			02812nam a22003975i 4500
001			81443
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007			cr nn 008mamaa
008			150929s2015 gw | s |||| 0|eng d
020			_a9783319192857
040			_aES-MaUEC
050		4	_aRC394.H85 _bR383 2015 EB
100	1		_aRüb, Udo _993869 _0Local
245	1	4	_aThe Neuropathology of Huntington�s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy _cby Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf
250			_a1st ed. 2015
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XIV, 146 p.) _b50 il., 47 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Anatomy, Embryology and Cell Biology _x0301-5556 _v217
520			_aThis monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aHuntington, Enfermedad de _9158834 _0comprobar BNE20012260459 _2embne
700	1		_aVonsattel, Jean Paul G. _993870 _0Local
700	1		_aHeinsen, Helmut _0Local _993871
700	1		_aKorf, Horst-Werner _993872 _0Local
830		0	_aAdvances in Anatomy, Embryology and Cell Biology _x0301-5556 _v217 _9133294
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-19285-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319192857
907			_a.b12900333 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b22-03-17 _cm _dz _eo _feng _ggw _h4
945			_aRC394.H85 R383 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11569955 _z06-04-17
999			_c81443 _d81443 _x1