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007			cr nn 008mamaa
008			150609s2015 gw | s |||| 0|eng d
020			_a9783319183268
024	7		_a10.1007/978-3-319-18326-8 _2doi
050		4	_aQP85 _b.L544 2015
245	1	0	_aLife Extension : _bLessons from Drosophila _cedited by Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VIII, 353 páginas) _b49 ilustraciones, 26 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHealthy Ageing and Longevity _x2199-9007 _v3
505	0		_aÂ{u0CA5}face -- SECTION I: Genetic regulation of longevity -- Mutations and quantitative genetic variation: lessons from Drosophila -- Modulation of Drosophila lifespan by neuronal genes -- Life span, stress resistance and age-dependent transcriptome dynamics in fruit flies with constitutive and conditional overexpression of GADD45 -- Superoxide dismutase over-expression and the mitochondrial unfolded protein response -- Effect of Wolbachia infection on aging and longevity-associated genes in Drosophila -- SECTION II: Drosophila models for aging-associated diseases -- Skeletal muscle homeostasis and aging -- Drosophila models of cardiac disease -- Genetic modulation of cardiac functional aging -- Functional links between circadian clocks, redox state and aging in Drosophila -- Drosophila models in therapeutic drug discovery -- SECTION III: Life-extending treatments -- Phytochemicals with lifespan extension effect in Drosophila -- Life extension in Drosophila by inhibitors of histone deacetylases -- Drosophila healthspan extension using dietary manipulation -- The effect of the artificial atmosphere on the fliesâ€{u0B2F}ngevity -- Effects of several mild stresses applied in adults on aging and longevity -- Life extension via stage-specific drug interventions in Drosophila -- Index.
520	3		_aThis book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in biogerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of healthspan, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader. Â{uE026}
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		0	_9140743 _aGeriatría _0
650		7	_aGenética animal _0 _2embne _9138513
650	2	7	_aCiencias biomédicas _0 _2embne _9143729
700	1		_aVaiserman, Alexander M _eeditor literario _993830 _0Local
700	1		_aMoskalev, Alexey A _eeditor literario _993831 _0Local
700	1		_aPasyukova, Elena G _eeditor literario _993832 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-18326-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12900126 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP85 .L544 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11569748 _z06-04-17
999			_c81422 _d81422 _x1