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008			150710s2015 gw | s |||| 0|eng d
020			_a9783319181448
024	7		_a10.1007/978-3-319-18144-8 _2doi
050		4	_aRA1247.H8 _bC446 2015
245	1	0	_aChemistry, Biochemistry and Pharmacology of Hydrogen Sulfide _cedited by Philip K. Moore, Matt Whiteman.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VI, 395 páginas) _b172 ilustraciones, 27 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHandbook of Experimental Pharmacology _x0171-2004 _v230
505	0		_aPart I Biochemistry, molecular biology and chemistry -- 1 H2Ssynthesizing enzymes: biochemistry and molecular aspects -- Part II Molecular mechanisms of action -- 2 Sulfhydration and H2S -- 3 Persulfide formation and H2S -- Part III Cardiovascular system -- 4 H2S and blood vessels - an overview -- 5 Hydrogen sulfide and urogenital tract -- 6 H2S - cardiac function and cardiac disease -- 7 H2S and platelets â€{u0860}possible role in thrombosis? -- Part IV Inflammation and inflammatory disease -- 8 H2S and inflammation Â{uD821}n overview -- 9 H2S and neuroinflammation -- Part V H2S and the nervous system -- 10 Brain, learning and memory: role in neurodegenerative diseases -- 11 H2S and pain â€{u0A6E}flammatory and neuropathic -- Part VI H2S, angiogenesis and cancer -- 12 H2S and colon cancer -- 13 The role of H2S in cancer and tumor development -- Part VII H2S and ageing -- 14 H2S â€{u0860}new approach to lifespan enhancement and healthy aging? -- Part VIII H2S, measurement and possible therapeutics? -- 15 Measurement of H2S â€{u0C32}obes comes of age? -- 16 S-propargylcysteine â€{u0860}novel H2S donor with therapeutic potential -- 17 Mitochondria-targetted sulfide donors -- 18 Medicinal chemistry - insights into the development of novel H2S donors.
520	3		_aThis book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aFisiología humana _0 _2embne _9140024
650		7	_aNeurociencias _0 _2embne _9158907
650		7	_aFarmacología _0 _2embne _9137893
700	1		_aMoore, Philip K _eeditor literario _993822 _0Local
700	1		_aWhiteman, Matt _eeditor literario _993823 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-18144-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12900084 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRA1247.H8 C446 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11569700 _z06-04-17
999			_c81418 _d81418 _x1