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008			150629s2015 gw | s |||| 0|eng d
020			_a9783319174372
024	7		_a10.1007/978-3-319-17437-2 _2doi
040			_aES-MaUEC _bspa
050		4	_aRC682 _b.C373 2015
245	1	0	_aCardiac Fibrosis and Heart Failure : _bCause or Effect? _cedited by Ian M.C. Dixon, Jeffrey T. Wigle.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XV, 436 páginas) _b73 ilustraciones, 59 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Biochemistry in Health and Disease _v13
505	0		_a1. Fibrosis and Heart Failure - Cause or Effect? -- 2. Fibroblast Activation in the Infarcted Myocardium -- 3. Mechanical and Matrix Regulation of Valvular Fibrosis -- 4. Bone Marrow-Derived Progenitor Cells, micro-RNA and Fibrosis -- 5. The Stressful Life of Cardiac Myofibroblasts -- 6. Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies Aldosteronism -- 7. Embryological origin of valve progenitor cells -- 8. Diverse cellular origins of cardiac fibroblasts -- 9. Non-Canonical Regulation of TGF-β1 Signaling: A Role for Ski/Sno and YAP/TAZ -- 10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart -- 11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis -- 12. Remodelling of the cardiac extracellular matrix:Â{u04AF}le of collagen degradation and accumulation inÂ{u0C21}thogenesis of heart failure -- 13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix Remodelling -- 14. Collagen processing and its role in Fibrosis -- 15. Mechanisms of Cardiac Fibrosis -- 16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and Myocytes -- 17. Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives -- 18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure -- 19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart -- 20. Cardiac Tissue Engineering for the Treatment of Heart Failure Post-Infarction -- 21. Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves.
520	3		_aThe unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated.Â{u01B5}rther, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood.This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM.Â{u2820} The book showcases chapters that highlight discussion of role of Transforming Growth Factor β (TGFβ), an important fibrogenic cytokine, and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented.The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood.Â{u026E} most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes.Â{u05A5}ry few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone.The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.
650		7	_aBiología molecular _2embne _9139103
650		7	_aCitología _2embne _9139477
650	2	7	_aCitología _2embne _9139477
700	1		_aDixon, Ian M. C. _eeditor literario _0Local _993807
700	1		_aWigle, Jeffrey T _eeditor literario _993808 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-17437-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12899975 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aRC682 .C373 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11569591 _z06-04-17
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0