000			04905nam a22003975i 4500
001			81347
003			ES-MaUEC
005			20230207040325.0
007			cr nn 008mamaa
008			150303s2015 gw | s |||| 0|eng d
020			_a9783319145440
024	7		_a10.1007/978-3-319-14544-0 _2doi
050		4	_aQP606.P76 _bP768 2015
245	1	0	_aProtein Kinase CK2 Cellular Function in Normal and Disease States _cedited by Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XXIII, 378 páginas) _b91 ilustraciones, 60 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Biochemistry in Health and Disease _v12
505	0		_a1. CK2 Suppression of Apoptosis -- 2. Structural Determinants of CK2 Regulation -- 3. Targeting Protein Kinase: CK2 Suppresses Pro-Survival Signaling Pathways and Growth of Gliobastoma -- 4. The Roles of CK2 in Drosophila Neurogenesis -- 5. Targeting the CK2 Subunit Interface: Challenge and Usefulness -- 6. CK2 in Wnt/β-catenin signaling and embryo development -- 7. Defective expression of CK2β promotes EMT and stemness properties both required for breast cancer progression -- 8. Chemical Biology Approaches to Identify CK2 Substrates and Perform Unbiased Evaluation of CK2 Inhibitors -- 9. Development of Screening Systems and Identification of Novel Potent Inhibitors of Human Protein Kinase CK2 -- 10. Protein Kinase CK2: At the Crossroad of Regulatory Cellular Pathways -- 11. Functional Regulation of DYRK Family Protein Kinases by Cellular Binding Partners -- 12. Regulation of CK2 in pancreatic β cells -- 13. Recent impressions from the configurational and conformational space captured by protein kinase CK2 -- 14. Role of CK2 in Plant Responses to Abiotic Stress -- 15. “Genuineâ€ásein Kinase: The False Sister of CK2: Phosphorylates-Secreted Proteins -- 16. CK2: â€{u0060}Novel Player in L-DOPA induced dyskinesia in a mouse model of Parkinsonâ€{u3824}isease -- 17. CK2 function in the regulation of Akt Pathway: new findings and perspectives -- 18. CK2 structure from yeast to human -- 19. Cellular zinc signaling is triggered by CK2 -- 20. A Nanomedicine Approach to Targeting CK2 for Cancer therapy -- 21. Bisubstrate approach for construction of high-affinity inhibitors and optical probes for protein kinase CK2.
520	3		_aThe field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2, continues to emerge as a major signaling molecule involved in diverse functions in health and disease. This kinase has unique features, most notably its ubiquitous and highly conserved nature. Its vast number of potential substrates exemplifies its involvement in various functions in cells under both the normal and diseased states. Of particular note is the observation that due to its ubiquitous nature, CK2 has been found to be dysregulated in all cancers that have been examined. As such, it is now being considered a potentially important target for cancer therapy. Protein Kinase CK2 plays equally important functions in development and intracellular activities, and has a global impact on cell growth and proliferation. An additional key function of CK2 is the impact of its activity on cell death processes. Given the vast nature of its functions, CK2 has been proposed to serve as a “master regulatorâ€{u0BE6} cell function. TheÂ{u3A21}pters included in this workÂ{u3BF6}er a wide range of topics dealing with some of the functions mentioned above, providingÂ{u1BA0}important starting point for research investigators and graduate students interested in this field.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aProteínas _2embne _9139861
650		7	_aApoptosis. _9157983 _2embne
650	2	7	_aProteínas _2embne _9139861
700	1		_aAhmed, Khalil _eeditor literario _993716 _0Local
700	1		_aIssinger, Olaf-Georg _eeditor literario _993717 _0Local
700	1		_aSzyszka, Ryszard _eeditor literario _993718 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-14544-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12899379 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP606.P76 P768 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11568999 _z06-04-17
999			_c81347 _d81347 _x1