000			03316nam a22003615i 4500
001			81336
003			ES-MaUEC
005			20230207040324.0
007			cr nn 008mamaa
008			150217s2015 gw | s |||| 0|eng d
020			_a9783319143408
024	7		_a10.1007/978-3-319-14340-8 _2doi
050		4	_aRC268.5 _bR634 2015
100	1		_aRobert, Jacques. _920913 _0comprobar BNE19900586896
245	1	0	_aTextbook of Cell Signalling in Cancer : _bAn Educational Approach _cby Jacques Robert.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XXIII, 328 páginas) _b126 ilustraciones, 122 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aGrowth Factors and Tyrosine Kinase Receptors -- MAP Kinases Pathway -- Phosphatidylinositol 3-Kinase Pathway -- Cytokine Pathway -- TGFβ Pathway -- G-proteinsâ€{u3BF5}pled Receptors -- Wnt Pathway -- Notch Pathway -- Hedgehog Pathway -- Integrins -- Semaphorins and Adhesion Molecules -- Toll-like Receptors, Interleukin 1 (IL1) and NFκB -- Lymphocyte Receptors Pathways -- Nuclear Receptors Pathways -- Ion Channelsâ€{u3BF5}pled Receptors -- Signalling by Oxygen and Nitric Oxide -- Cell Cycle Control -- Apoptosis Induction and Regulation.
520	3		_aThis book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis. This comprehensive reference text is based on the masterâ€{u3823}ourses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aBiología molecular _2embne _9139103
650		7	_aCitología _2embne _9139477
650		7	_aFarmacología _2embne _9137893
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-14340-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12899264 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRC268.5 R634 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11568884 _z06-04-17
999			_c81336 _d81336 _x1