000			03577nam a22003975i 4500
710	2		_aSpringerLink (Online service) _0Local _9106996
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008			141211s2015 gw | s |||| 0|eng d
020			_a9783319127309
024	7		_a10.1007/978-3-319-12730-9 _2doi
040			_aES-MaUEC
050		4	_aRC271.P43 _bR475 2015
245	1	0	_aResistance to Photodynamic Therapy in Cancer _cedited by Valentina Rapozzi, Giulio Jori.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XV, 248 páginas) _b48 ilustraciones, 36 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aResistance to Targeted Anti-Cancer Therapeutics _x2196-5501 _v5
505	0		_aBasic and Clinical Aspects of photodynamic Therapy -- Mechanisms of Resistance to Photodynamic Therapy -- Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy -- Autophagy Pathways Activated in Response to PDT Contribute to Cell Resistance Against ROS Damage -- Methods to isolate the Resistant Cells to Photodynamic Therapy -- GRP78-Targeting Subtilase Cytotoxin Sensitizes Cancer Cells to Photodynamic Therapy -- Optimization of Photodynamic Therapy Response by Survivin Gene Knockdown in Human Metastatic Breast Cancer -- Cellular Targets and Molecular Responses Associated with Photodynamic Therapy -- The Use of Nanoparticle-Delivered Photosensitizers Can Overcome the Development of Resistance to PDT in Tumors -- Mechanisms of tumor cells resistance to ALA/PDT -- Overcoming the Resistance of Meolanoma to Photodynamic Therapy.
520	3		_aThis volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
650		7	_aResistencia a los medicamentos _2embne _9146972
650		7	_aBiología molecular _2embne _9139103
650	2	7	_aBiología molecular _2embne _9139103
700	1		_aRapozzi, Valentina _eeditor literario _993652 _0Local
700	1		_aJori, Giulio _eeditor literario _993653 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-12730-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12898934 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aRC271.P43 R475 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11568550 _z06-04-17
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0