000			03333nam a22003735i 4500
001			81273
003			ES-MaUEC
005			20230207040322.0
007			cr nn 008mamaa
008			140923s2015 gw | s |||| 0|eng d
020			_a9783319105338
040			_aES-MaUEC
050		4	_aQP624.5.R48 _bG556 2015 EB
100	1		_aGlinkowska, Monika _993606 _0Local
245	1	0	_aDNA Replication Control in Microbial Cell Factories _cby Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (V, 50 p.) 4 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Microbiology _x2191-5385
520			_aThis work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control ofÂ{u0863}tivity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition,Â{u3A6D}ilarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, andÂ{u9B70}lications for understanding more complex processes, like carcinogenesis are suggested. Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling ofÂĎA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context ofÂ{u4A25} current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aADN _xReplicación _9301511 _0comprobar BNE20003536276 _2embne
700	1		_aBoss, Lidia _0Local _993607
700	1		_aWegrzyn, Grzegorz. _993608 _0Local
830		0	_aSpringerBriefs in Microbiology _x2191-5385 _9133168
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-10533-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319105338
907			_a.b12898636 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b10-03-17 _cm _dz _eo _feng _ggw _h0
945			_aQP624.5.R48 G556 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11568252 _z06-04-17
999			_c81273 _d81273 _x1