000			03356nam a22004455i 4500
001			81237
003			ES-MaUEC
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007			cr nn 008mamaa
008			150813s2015 gw | s |||| 0|eng d
020			_a9783319087177
024	7		_a10.1007/978-3-319-08717-7 _2doi
050		4	_aQP551 _b.A336 2015
082	0	4	_a572.6
245	1	0	_aADAMTS13 : _bBiology and Disease _cedited by George M. Rodgers.
250			_a1st ed. 2015.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (X, 186 p.) _b33 ilustraciones, 24 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. A13: Structure and function -- 2. A13: The von Willebrand factor cleaving protease -- 3. A13: Angiogenesis and other biologic activities -- 4. A13:Â{u0073}says -- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome) -- 6. Acquired A13 deficiency (TTP) -- 7. Related thrombotic microangiopathies -- 8. Future directions.
520			_aThis comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Âïmprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		0	_9430647 _aProteómica _0LocalX
650		7	_aCitología _0LocalX _2embne _9139477
650	2	4	_9430647 _aProteómica _0LocalX
650	2	7	_aCitología _0LocalX _2embne _9139477
650		0	_9495993 _aCiencias de la vida _0LocalX
650	1	4	_9495993 _aCiencias de la vida _0LocalX
650		0	_9140122 _aHematología _0LocalX
650	2	4	_9140122 _aHematología _0LocalX
700	1		_aRodgers, George M _eeditor literario _993568 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-08717-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12898272 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP551 .A336 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567892 _z06-04-17
999			_c81237 _d81237 _x1