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008			151125s2015 sz | s |||| 0|eng d
020			_a9783034809559
024	7		_a10.1007/978-3-0348-0955-9 _2doi
040			_dES-MaUEC
050		4	_aQP623.5.S63 _bC573 2015
245	1	0	_aCirculating microRNAs in Disease Diagnostics and their Potential Biological Relevance _cedited by Peter Igaz.
250			_a1st ed. 2015.
260			_aBasel _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XII, 288 p.) _b18 ilustraciones, 15 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aExperientia Supplementum _x1023-294X _v106
505	0		_aPart I: General features and technical issues related to circulating microRNA -- 1. Introduction to microRNAs: biogenesis, action, relevance of tissue microRNAs in disease pathogenesis, diagnosis and therapy. The concept of circulating microRNAs -- 2. Extracellular microRNAs in membrane vesicles and non-vesicular carriers -- 3. Technical aspects related to the analysis of circulating microRNAs -- Part II: Diagnostic relevance of circulating microRNAs -- 4. Circulating blood-borne microRNAs as biomarkers in solid tumors -- 5. Circulating microRNA as biomarkers in hematological malignancies -- 6 Circulating microRNAs as biomarkers in cardiovascular diseases -- 7 Circulating microRNAs in neurodegenerative diseases -- 8 Circulating extracellular microRNA in systemic autoimmunity -- 9. Circulating microRNAs in inflammatory bowel diseases -- 10. Circulating microRNAs in diabetes progression: discovery, validation and research translation -- 11. Diagnostic relevance of microRNAs in other body fluids including urine, feces and saliva -- Part III: Potential biological relevance of circulating microRNA -- 12 Circulating microRNAs as hormones â€{u0A6E}tercellular and inter-organ conveyors of epigenetic information? -- 13. Are circulating microRNAs involved in tumor surveillance? -- 14.-Hypothetic interindividual and interspecies relevance of microRNAs released in body fluids.
520			_aMicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
650		7	_2embne _9140525 _aÁcidos nucleicos
700	1		_aIgaz, Peter _eeditor literario _0Local _993545
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-0348-0955-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12898144 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aQP623.5.S63 C573 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567764 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gsz _h0