000			04111nam a22003495i 4500
999			_c81214 _d81214 _x1
001			81214
003			ES-MaUEC
005			20230207040319.0
007			cr nn 008mamaa
008			150821s2015 xxu| s |||| 0|eng d
020			_a9781493929047
024	7		_a10.1007/978-1-4939-2904-7 _2doi
040			_dES-MaUEC
050		4	_aQH603.C96 _bT443 2015
245	1	4	_aThe Cytoskeleton in Health and Disease _cedited by Heide Schatten.
250			_a1st ed. 2015.
260			_aNew York _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XII, 395 p.) _b55 ilustraciones, 42 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart 1. Overview of the Cytoskeleton -- Brief Overview of the Cytoskeleton -- Part 2. Focus on Cytoskeletal Interactions -- Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats -- Regulation of Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease -- The Role of the Cytoskeleton in Cell Migration, Its Influence on Stem Cells and the Special Role of GFAP in Glial Functions -- Centrosome-Microtubule Interactions in Health, Disease, and Disorders -- Cytoskeletal Elements and Reproductive Success in Animals -- Part 3. Focus on Microtubules -- Cytoskeleton and Regulation of Mitochondrial Translocation in Mammalian Eggs -- Tubulin Detyrosination in Epithelial Cells -- Mutations in Adenomatous Polyposis Coli, Their Role in Cytoskeletal Dynamics and Cancer Onset -- Small GTPases Act as Cellular Switches in the Context of Cilia -- Part 4. Focus on Intermediate Filaments -- Desmin Plays Dual Structural and Regulatory Functions Through Its Interaction with Partners in Muscle -- Desmin Filaments and Desmin-Related Myopathy -- Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes -- Part 5. Focus on Microfilaments -- Actin Organizing Proteins in Regulation of Osteoclast Function -- The Role of Drebrin-Binding Stable Actin Filaments in Dendritic Spine Morphogenesis -- The Role of the Actin Cytoskeleton in Cancer and Its Potential Use as a Therapeutic Target.
520			_aThis volumeÂ{u5E30}lores the cytoskeleton, examining its structural and functional roles and its dysfunctions which often lead to disease.Â{uDA63}crotubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems are thoroughly discussed. The text is organized into four sections, each of which coversÂ{u3C25}cific subtopics. These consist ofÂ{u1BA0}introductory chapterÂ{u6BEC}lowed by topics of current interest and expert-provided contributions whichÂ{u9BA3}lude each topic'sÂ{uB979} cell and molecular details. ComprehensiveÂ{u9974} concise,Â{u2814}The Cytoskeleton in Health and DiseaseÂ{u0CA5}sents cutting- edge newÂ{uBBAF}wledgeÂ{u286C}anced with background information, both of which are readily understandable for the newcomer and for the experienced researcher alike. The bookÂ{u8A67}hlights the new aspects of theÂ{u2973}earch and its impact onÂ{u0D28}e design ofÂ{uE977} strategies or the identification of new targets for therapeutic intervention. This book will be essential reading for scientists, students, teachers who are interested in expanding their knowledge related to the cytoskeleton for diagnostic, therapeutic orÂ{u2973}earch-based purposes.
650		7	_2embne _9165668 _aFisiología celular
700	1		_aSchatten, Heide _eeditor literario _985112 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-2904-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12898041 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aQH603.C96 T443 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567661 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h4