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003			ES-MaUEC
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007			cr nn 008mamaa
008			150508s2015 xxu| s |||| 0|eng d
020			_a9781493924806
024	7		_a10.1007/978-1-4939-2480-6 _2doi
040			_dES-MaUEC
050		4	_aQL739.23 _bC455 2015
245	1	0	_aCell Signaling During Mammalian Early Embryo Development _cedited by Henry J. Leese, Daniel R. Brison.
260			_aNew York _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XII, 216 p.) _b21 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v843
520			_aThe book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.
650		7	_2embne _9323233 _aMamíferos _xReproducción
700	1		_aLeese, Henry J. _eeditor literario _0Local _993496
700	1		_aBrison, Daniel R. _eeditor literario _0Local _993497
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-2480-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12897887 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aQL739.23 C455 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567508 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0