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008			150427s2015 xxu| s |||| 0|eng d
020			_a9781493924042
024	7		_a10.1007/978-1-4939-2404-2 _2doi
040			_dES-MaUEC
050		4	_aQP85 _b.L664 2015
245	1	0	_aLongevity Genes : _bA Blueprint for Aging _cedited by Gil Atzmon, PhD.
260			_aNew York _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XI, 194 p.) _b18 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v847
505	0		_aEvolutionary Genetic Bases of Longevity and Senescence -- Candidate Genes That Affect Aging Through Protein Homeostasis -- Autophagy and Aging -- A Genetic View of the Mitochondrial Role in Aging: Killing Us Softly -- GWAS and Meta-analysis in Aging/Longevity -- Exome and Whole Genome Sequencing in Aging and Longevity -- Models to Explore Genetics of Human Aging -- Systems Biology of Aging -- Epigenetics of Aging.
520			_aThe release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolvingÂ{u5BA4}erstanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for AgingÂ{u5E30}lores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. ItÂ{u4BF5}ches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describesÂ{u4A25} hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly,Â{u3BEE}sidering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
650		7	_2embne _9144609 _aLongevidad
700	1		_aAtzmon, Gil _eeditor literario _0Local _993486
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-2404-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b1289784x _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aQP85 .L664 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567466 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0