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008			141126s2015 xxu| s |||| 0|eng d
020			_a9781493920532
024	7		_a10.1007/978-1-4939-2053-2 _2doi
040			_dES-MaUEC
050		4	_aQP606.P78 _bR434 2015
245	1	0	_aReceptor Tyrosine Kinases : _bStructure, Functions and Role in Human Disease _cedited by Deric L. Wheeler, Yosef Yarden.
260			_aNew York _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XVII, 440 p.) _b56 ilustraciones, 51 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aThe Eukaryotic Protein Kinase Superfamily -- Evolution of Receptor Tyrosine Kinases -- RTKs in Invertebrates: Lessons in Signal Transduction -- Cell Signaling by Receptor Tyrosine Kinases -- Nuclear Signaling of Receptor Tyrosine Kinases -- Computational and Modeling Aspects of RTK Networks -- Endocytosis of Receptor Tyrosine Kinases -- Structural Features of the Ligand-Binding Extracellular Domain -- Structural Features of the Kinase Domain -- Targeting RTKs in Cancer.-Â{u036F}use Models of Receptor Tyrosine Kinases.
520			_aReceptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.
650		7	_2embne _9138640 _aEnzimas
700	1		_aWheeler, Deric L _eeditor literario _993460 _0Local
700	1		_aYarden, Yosef _eeditor literario _984709 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-2053-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12897681 _b10-10-17 _c18-01-16
942			_2lcc _cLE
945			_aQP606.P78 R434 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567302 _z06-04-17
988			_aEBSPRINGER
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