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008			141031s2015 xxu| s |||| 0|eng d
020			_a9781493913992
024	7		_a10.1007/978-1-4939-1399-2 _2doi
050		4	_aRM301.25 _bD573 2015
245	1	0	_aDiscovering and Developing Molecules with Optimal Drug-Like Properties _cedited by Allen C Templeton, Stephen R. Byrn, Roy J Haskell, Thomas E. Prisinzano.
260			_aNew York _bSpringer _c2015
300			_a1 recurso en línea (XI, 511 páginas) _b161 ilustraciones, 130 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAAPS Advances in the Pharmaceutical Sciences Series _x2210-7371 _v15
505	0		_a1 Developability Assessment and Risk Management During Drug Discovery -- 2 Discovery Formulations â€{u0070}proaches and Practices in Early Preclinical Development -- 3 Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes -- 4 Diagnosing Biopharmaceutical Limitations -- 5 The Importance of Molecular Design Principles in Delivering High Quality Pharmaceutical Candidates -- 6 Predictive Approaches to Establishing, Understanding, and Communicating Risk with Emphasis on Early Development -- 7 Strategies and Methods for Drug Candidate Phase Optimization in Discovery Space -- 8 Efficient Laboratory Methods to Assess Risk and Design Formulations -- 9 Advanced X-ray Analytical Methods to Understand Structure, Properties and Risk -- 10 Performance and Characterization of Amorphous Solid Dispersions: An Overview -- 11 Hot-Melt Extrusion: The Process-Product-Performance Interplay -- 12 Practical Considerations for Spray Dried Formulation and Process Development -- 13 Nanosizing: “End-to-Endâ€Ưrmulation Strategy for Poorly-Water- Soluble Molecules -- 14 Leveraging Solid State Form and Physiochemical Properties for Early Clinical Formulation Efforts:Â{uFC30}portunities and Challenges during Telcagepant Liquid Capsule Development.
520	3		_aThis authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias, EBSPRINGER,
650		7	_aTecnología farmacéutica _0 _2embne _9161127
650	2	7	_aFarmacia _0 _2embne _9137891
700	1		_aTempleton, Allen C _eeditor literario _993436 _0Local
700	1		_aByrn, Stephen R. _eeditor literario _0Local _993437
700	1		_aHaskell, Roy J. _eeditor literario _0Local _993438
700	1		_aPrisinzano, Thomas E _eeditor literario _993439 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1399-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12897577 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0
945			_aRM301.25 D573 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11567193 _z06-04-17
999			_c81167 _d81167 _x1