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008			130902s2014 au | s |||| 0|eng d
020			_a9783709115350
024	7		_a10.1007/978-3-7091-1535-0 _2doi
040			_dES-MaUEC
050		4	_aRD771.I6 _bT445 2014
245	1	4	_aThe Intervertebral Disc : _bMolecular and Structural Studies of the Disc in Health and Disease _cedited by Irving M. Shapiro, Makarand V. Risbud.
260			_aVienna _bSpringer International Publishing _c2014
300			_a1 recurso en línea (X, 446 p.) _b130 ilustraciones, 42 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aBiomechanical and Molecular Studies of the Intervertebral Disc: Introduction to the Structure, Function and Comparative Anatomy of the Vertebrae and the Intervertebral Disc -- The Intervertebral Disc: Overview of Disc Mechanics -- Development of the Intervertebral Disc -- Proteoglycans of the Intervertebral Disc -- Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus and Cartilage Endplates -- Microenvironmental Regulation of Cell Function and Extracellular Matrix Synthesis by Disc Cells -- The Effects of Mechanical Forces on Nucleus and Annulus Cells -- The Role of the ADAMTS Proteins in the Intervertebral Disc -- Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities: Epidemiology of Lumbar Disc Degeneration -- Genetic Basis of Intervertebral Disc Degeneration -- Pathogenesis of Intervertebral Disc Degeneration -- Imaging Modalities for Studying Disc Pathology -- Surgical Indications for Lumbar Degenerative Disease -- Spinal Motion Restoration Devices for the Degenerate Disc -- The Non-Surgical Treatment of Back Pain -- Back Pain and Disc Degeneration: Are They Linked?- Clinical Features and Pathobiology of Chordoma -- Models of Disc Disease and Biological Regeneration: Large Animal Models of Disc Degeneration -- Intervertebral Disc Herniation -- The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Generation -- Use of Knockout and Transgenic Mouse Models in Disc Research -- Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair -- Use of Stem Cells to Regenerate the Disc -- Gene Therapy Approaches for Disc Regeneration -- Enhancing Disc Repair by Growth Factors and Other Modalities -- Tissue Engineering of the Disc.
520			_aThe intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians,Â{u4A29}s is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies for mitigating the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is dedicated to approaches that model normal development, and the elucidation of the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques.This unique and authoritative book bridges the gap between the basic and clinical sciences; its target audience includes basic scientists, orthopedists, neurologists, rehabilitation and physical therapists, primary care physicians and chiropractors, while it also addresses the needs ofÂ{u7CA1}duate students, medical students, interns, fellows, and patients who suffer from disc-related pathologies.
650		7	_2embne _9677239 _aDiscos intervertebrales
700	1		_aShapiro, Irving M _eeditor literario _988958 _0Local
700	1		_aRisbud, Makarand V _eeditor literario _988959 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-7091-1535-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12883748 _b10-10-17 _c11-11-15
942			_2lcc _cLE
945			_aRD771.I6 T445 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11563564 _z06-04-17
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998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _gau _h4