000			02923nam a22003855i 4500
999			_c80583 _d80583 _x1
001			80583
003			ES-MaUEC
005			20230207040311.0
007			cr nn 008mamaa
008			140422s2014 gw | s |||| 0|eng d
020			_a9783642544903
024	7		_a10.1007/978-3-642-54490-3 _2doi
040			_aES-MaUEC
050		4	_aRC268.4 _b2014 EB
245	1	0	_aSmall Molecules in Oncology _cedited by Uwe M. Martens.
250			_a2nd ed. 2014
260			_aBerlin, Heidelberg _bSpringer _c2014
300			_a1 recurso en línea (XVI, 417 páginas) _b46 ilustraciones, 26 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aRecent Results in Cancer Research _x0080-0015 _v201
505	0		_aImatinib Mesylate -- Erlotinib -- Axitinib (AG-013736) -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Decitabine -- Azacytidine/Azacitidine -- Bortezomib -- Temsirolimus -- Danusertib -- Vismodegib -- Everolimus -- Vemurafenib -- Vandetanib -- Trametinib -- Dabrafenib -- Ponatinib -- Regorafenib -- Cabozantinib -- Revlimid -- Ibrutinib -- Qizartinib -- Ruxolitinib -- Carfilzomib -- Afitinib.
520	3		_aExtensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
650		7	_aCáncer _xAspectos genéticos _2embne _9273952
650		7	_aOncología _2embne _9139207
700	1		_aMartens, Uwe M _eeditor literario _988893 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-54490-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12883360 _b10-10-17 _c11-11-15
942			_2lcc _cLE
945			_aRC261 .S635 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11563187 _z06-04-17
988			_aEBOOK, asignarmaterias, EBSPRINGER,
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _ggw _h0