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008			140430s2014 gw | s |||| 0|eng d
020			_a9783642540660
024	7		_a10.1007/978-3-642-54066-0 _2doi
040			_dES-MaUEC
050		4	_aRL106.M65 _bH675 2014
100	1		_aHosler, Gregory A. _988875 _0Local
245	1	0	_aMolecular Diagnostics for Dermatology : _bPractical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient _cby Gregory A. Hosler, Kathleen M. Murphy.
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XVIII, 356 p.) _b83 ilustraciones, 79 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction -- Terms and Definitions -- Basics of Molecular Biology and Nucleic Acids -- Principles of the Molecular Basis for Disease -- Molecular Testing Methods -- PCR and PCR-based Assays -- In situ Hybridization -- FISH and Cytogenetics -- Comparative Genomic Hybridization -- Microarray Analysis -- Melanoma -- Cutaneous Lymphoma and Leukemia Cutis -- Soft Tissue tumors -- Genodermatoses -- Infectious Disease -- Viral -- Bacterial and Mycobacterial -- Fungi and Parasites -- Emerging Molecular Applications in Dermatology -- Pharmacogenetics/Pharmacogenomics -- Theranostics.
520			_aThis textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers â€{u08EC}inicians, pathologists, laboratorians, and other inquisitive minds â€{u0A6E}dependent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing “excise and prayâ€{u0870}proaches with personalized medicine.
650		7	_2embne _aDermatología _9139590
700	1		_aMurphy, Kathleen M. _988876 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-54066-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12883244 _b10-10-17 _c11-11-15
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