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008			131125s2014 gw | s |||| 0|eng d
020			_a9783642387654
024	7		_a10.1007/978-3-642-38765-4 _2doi
040			_dES-MaUEC
050		4	_aRL71 _b.H377 2014
100	1		_aHapple, R. _q(Rudolf) _988736 _eautor
245	1	0	_aMosaicism in Human Skin : _bUnderstanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia _cby Rudolf Happle
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIII, 229 p.) _b232 ilustraciones, 208 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPATTERNS AND MECHANISMS: Mosaicism as a Biological Concept: -- History -- Mosaicism in Plants, Animals, Humans -- Mosaicism Versus Chimerism -- The Mechanisms of Mosaicism -- Genomic Mosaicism of Autosomes -- Epigenetic Mosaicism of autosomes -- Genomic Mosaicism of X Chromosomes -- Epigenetic Mosaicism of X Chromosomes -- The patterns of Mosaicism -- Lines of Blaschko -- Checkerboard Pattern -- Phylloid Pattern -- Patchy Pattern Without Midline Separation -- Lateralization -- Other Patterns, so far Unclassifiable -- MOSAIC SKIN DISORDERS: Nevi -- Melanocytic Nevi -- Other Forms of Pigmentary Mosaicism -- Epidermal Nevi -- Vascular Nevi -- Connective Tissue Nevi -- Nevoid Skin Disorders -- Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders -- Autosomal Non-Nevi -- Neoplastic Skin Lesions -- Benign Tumors -- Malignant Tumors -- CONCLUSION.
520			_aMosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devotedÂ{u4BE0}the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
650		7	_2embne _aDermatología _9139590
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-38765-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12882501 _b10-10-17 _c11-11-15
942			_2lcc _cLE
945			_aRL71 .H377 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11562328 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _ggw _h0