000			04268nam a22003615i 4500
001			80413
003			ES-MaUEC
005			20230207040304.0
007			cr nn 008mamaa
008			140602s2014 gw | s |||| 0|eng d
020			_a9783319054704
024	7		_a10.1007/978-3-319-05470-4 _2doi
050		4	_aR850 _b.E874 2014
245	1	0	_aEssentials of Clinical Research _cedited by Stephen P. Glasser.
250			_a2nd ed. 2014.
260			_aCham, Switzerland _bSpringer _c2014
300			_a1 recurso en línea (VI, 461 páginas) _b80 ilustraciones, 42 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- The Beginning, Historical Aspects of Clinical Research, Clinical Research: Definitions, “Anatomy and Physiology,â€{u086E}d the Quest for “Universal Truthâ€{u0B6D} Introduction to Clinical Research Concepts, Essential Characteristics of Clinical Research, Overview of Clinical Research Study Designs -- A Focus on Clinical Trials -- Alternative Interventional Study Designs -- Phase 4 (Postmarketing) Research -- The Role of the USA Food and Drug Administration in Clinical Research -- The Placebo and Nocebo Effect -- Recruitment and Retention in Clinical Research -- Data Safety and Monitoring Boards (DSMBs) -- Meta-analysis, Evidence Based Medicine, and Clinical Guidelines -- Research Methods for Genetic Studies -- Research Methods for Pharmacoepidemiology Studies -- Implementation Research: Beyond the Traditional Randomized Controlled Trial -- Research Methodology for Studies of Diagnostic Tests -- Statistical Power & Sample Size: Some Fundamentals For Clinician Researchers -- Association, Cause, and Correlation -- Bias, Confounding, and Effect Modification (Interaction) -- Itâ€{u3801}ll About Uncertainty -- Grant and Manuscript Writing -- The Media and Clinical Research -- Mentoring and the Mentee -- Presentation Skills: How to Present Research Results.
520	3		_aIn its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias, EBSPRINGER,
650	2	7	_aCiencias biomédicas _0 _2embne _9143729
650		7	_aMedicina clínica _xResearch _0(OCoLC)864379 _2embne _0 _9138380
700	1		_aGlasser, Stephen P. _eeditor literario _0Local _988560
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-05470-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12881661 _b10-10-17 _c11-11-15
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _ggw _h0
945			_aR850 .E874 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11561488 _z06-04-17
999			_c80413 _d80413 _x1