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008			131025s2014 gw | s |||| 0|eng d
020			_a9783319022017
024	7		_a10.1007/978-3-319-02201-7 _2doi
050		4	_aRM301.25 _bA673 2014
245	1	2	_aA Practical Guide to Drug Development in Academia : _bThe SPARK Approach _cedited by Daria Mochly-Rosen, Kevin Grimes.
260			_aCham, Switzerland _bSpringer _c2014
300			_a1 recurso en línea (XII, 176 páginas) _b9 ilustraciones, 4 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringerBriefs in Pharmaceutical Science & Drug Development _x1864-8118
505	0		_aAdvancing New Treatments to the Clinic within Academia -- Overview of Drug Discovery and Development -- Assessing Clinical Need -- Target Product Profile (TPP) -- Project Management and Project Planning -- Robustness of Preclinical Studies -- Repurposing Drugs -- Developing Assays for High Throughput Screening (HTS) -- Medicinal Chemistry and Lead Optimization -- Vaccine Development -- When to Begin Animal Studies -- In vivo pharmacology: Multiple Roles in Drug Discovery -- Pharmacokinetics and ADME Properties -- Route of Administration and Drug Formulation -- Preclinical Safety Studies -- Regulatory Considerations in Product Development -- Manufacturing and Quality Control -- Technical Development and Manufacturing of Biological Products -- Clinical Trial Design -- Overview of Clinical Trials -- Intellectual Property -- Working with the University Technology Transfer Office -- Avoiding Conflicts of Interest -- Working with the University Compliance Office -- Selecting the Market for Your Drug -- Commercial Assessments -- Making a Compelling Pitch to Potential Investors -- Venture Capital Funding -- Not-For-Profit Drug Development -- Legal Aspects of a Start-up Biotechnology Company -- Founder Preferred Stock -- Plan, Organize, Motivate and Control -- A Call to Action: Changing How We Pursue Drug Discovery and Development.
520	3		_a"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review from Nature Chemical Biology Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed â€t̃oo earlyâ€{u0D2F} attract industry interest.Â{u4A25}re are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.Â{u5863}ch chapter broadly discusses an important topic in drug development,Â{u6CAF}m preclinical work in assay design through clinical trial design, regulatory issues and marketing assessments.Â{u19B4}ter the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest. "I would actually welcome it if this bookâ€{u3829}ntended audience were broadened even more. Younger scientists starting out in the drug industry would benefit from reading it and getting some early exposure to parts of the process that theyâ€{uCB20}eventually have to understand. Journalists covering the industry (especially the small startup companies) will find this book a good reality check for many an over-hopeful press release. Even advanced investors who might want to know what really happens in the labs will find information here that might otherwise be difficult to track down in such a concentrated form.".
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias, EBSPRINGER,
650		7	_aTecnología farmacéutica _0 _2embne _9161127
650	2	7	_aFarmacia _0 _2embne _9137891
700	1		_aMochly-Rosen, Daria _eeditor literario _988491 _0Local
700	1		_aGrimes, Kevin _eeditor literario _988492 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-02201-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12881284 _b10-10-17 _c11-11-15
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _ggw _h2
945			_aRM301.25 A673 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11561105 _z06-04-17
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