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007			cr nn 008mamaa
008			140402s2014 xxu| s |||| 0|eng d
020			_a9781489974365
024	7		_a10.1007/978-1-4899-7436-5 _2doi
040			_dES-MaUEC
050		4	_aRJ482.B65 _bB664 2014
245	1	0	_aBone Drugs in Pediatrics : _bEfficacy and Challenges _cedited by Gordon L. Klein.
260			_aBoston, MA _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIII, 233 p.) _b45 ilustraciones, 28 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction -- Developmental Pharmacokinetics: Drug Disposition Relative to Age -- Drug Development for Pediatric Diseases with Bone Loss -- Pediatric Bone Physiology and Monitoring Safety and Efficacy of Bone Drugs in Children -- Bisphosphonates in Osteogenesis Imperfecta -- Use of Bisphosphonates in Genetic Diseases Other Than Osteogenesis Imperfecta -- Bisphosphonates in Pediatric Burn Injury -- Growth Hormone and Bone -- Growth Hormone and Oxandrolone in Burned Children -- Pediatric Bone Drugs: Calcium and Vitamin D -- Pediatric Maxillofacial Conditions and Drugs -- Newer Adult Bone Drugs -- Conclusion: Whither (or Wither?) the Pharmacology on Pediatric Bone?.
520			_aBone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves â€{u0CF5}ch as bisphosphonates, anti-resorptives and anabolic agents â€{u0DE9}thin the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs inÂ{u6D74}ure treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.
650		7	_2embne _9169082 _aHuesos _xEnfermedades
700	1		_aKlein, Gordon L. _eeditor literario _0Local _988289
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4899-7436-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12880127 _b10-10-17 _c11-11-15
942			_2lcc _cLE
945			_aRJ482.B65 B664 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11559949 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _gxxu _h0