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003			ES-MaUEC
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007			cr nn 008mamaa
008			140107s2014 xxu| s |||| 0|eng d
020			_a9781461495451
024	7		_a10.1007/978-1-4614-9545-1 _2doi
040			_dES-MaUEC
050		4	_aQH634.5 _bT866 2014
245	1	0	_aTumor Metabolome Targeting and Drug Development _cedited by Steven Kanner.
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 198 p.) _b22 ilustraciones, 12 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aCancer Drug Discovery and Development _x2196-9906
505	0		_aTumor cell metabolic reprogramming and drug targeting -- Cancer metabolism: a nexus of matter, energy and reactive oxygen species -- Regulating mitochondrial respiration in cancer -- Regulation of cancer cell metabolism by hypoxia -- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs -- Modulating autophagy and the “reverse Warburg effectâ€{u0B6D} Metabolic adaptation in reprogrammed cancer cells -- Index.
520			_aIn this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.Âȯwever, the metabolism of malignant cells generally varies from that of normal cells.These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic optionsÂ{u04EF}me of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverseâ€סrburg effect--these topics and more are discussed in this volume. Â{uE000}
650		7	_2embne _aMetabolismo _9138638
700	1		_aKanner, Steven _eeditor literario _988274 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-9545-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12880024 _b10-10-17 _c11-11-15
942			_2lcc _cLE
945			_aQH634.5 T866 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11559846 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _gxxu _h0