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001			80216
003			ES-MaUEC
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007			cr nn 008mamaa
008			140408s2014 xxu| s |||| 0|eng d
020			_a9781461488156
024	7		_a10.1007/978-1-4614-8815-6 _2doi
050		4	_aRC280.H4 _bM654 2014
245	1	0	_aMolecular Determinants of Head and Neck Cancer _cedited by Barbara Burtness, Erica A. Golemis.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (IX, 362 páginas) _b44 ilustraciones, 40 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aCurrent Cancer Research
505	0		_aOverview: The Pathobiology of Head and Neck Cancer -- Human papillomavirus (HPV)-positive head and neck cancer and the Wnt signaling pathway -- EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer -- The Role of HGF/c-MET in Head and Neck Squamous Cell Carcinoma -- Insulin-like Growth Factor-1 Receptors in Head and Neck Cancer -- The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma -- Jak/STAT Signaling in HNC -- TGFβ regulates EMT in head and neck cancer -- p53 in Head and Neck Cancer -- DNA damage proteins and response to therapy in head and neck cancer -- Hypoxia and radioresistance in head and neck cancer -- The Wnt β-catenin Signaling Circuitry in Head and Neck Cancer -- Sequencing HNC: Emergence of Notch Signaling -- Gene Expression in HNC -- Epidemiology of HPV in Head and Neck Cancer; variant strains, discrete protein function -- Projections: Novel Therapies for HPV-Negative Cancers of the Head and Neck -- Index.
520	3		_aHead and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias, EBSPRINGER,
650	2	7	_aProteínas _0 _2embne _9139861
650		7	_aCuello _xCáncer _0(OCoLC)1035351 _2embne _0 _9210887
700	1		_aBurtness, Barbara _eeditor literario _988220 _0Local
700	1		_aGolemis, Erica A. _eeditor literario _0Local _988221
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-8815-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12879691 _b10-10-17 _c11-11-15
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _gxxu _h0
945			_aRC280.H4 M654 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11559512 _z06-04-17
999			_c80216 _d80216 _x1