000			03445nam a22003975i 4500
999			_c80013 _d80013 _x1
001			80013
003			ES-MaUEC
005			20230207040250.0
007			cr nn 008mamaa
008			131123s2014 xxu| s |||| 0|eng d
020			_a9780387756134
024	7		_a10.1007/978-0-387-75613-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM267 _b.F863 2014
082	0	4	_a616.9
245	1	0	_aFundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics _cedited by Alexander A. Vinks, Hartmut Derendorf, Johan W. Mouton.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (IX, 466 p.) _b110 ilustraciones, 12 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aForeword -- Section I: Basic Concepts and Principles -- Introduction to Pharmacodynamics and micrbiology -- In vitro and animal PK/PD model -- MIC and breakpoints -- Principles of applied PK/PD modeling -- Population Pk/PD modeling and its applications to antimicrobials -- Drug resistance and Drug-drug combinations -- Section II: Clinical -- Aminoglycosides -- Beta-lactam antibiotics including continuous infusion -- Macrolides -- Glycopeptides -- Quinolones -- Other.-Â{u2802}Â{u2802}Â{u282E}.
520			_aOver the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and PharmacodynamicsÂ{u0A73} designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.
650		7	_aToxicología _2embne _9140328
650		7	_aEnfermedades infecciosas _2embne _9138404
700	1		_aVinks, Alexander A _eeditor literario _987833 _0Local
700	1		_aDerendorf, Hartmut _eeditor literario _986812 _0Local
700	1		_aMouton, Johan W _eeditor literario _987834 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-0-387-75613-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12877669 _b10-10-17 _c11-11-15
942			_2lcc _cLE
945			_aRM267 .F863 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11557485 _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b11-11-15 _cm _dz _e- _feng _gxxu _h0