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008			141020s2014 ii | s |||| 0|eng d
020			_a9788132220534
024	7		_a10.1007/978-81-322-2053-4 _2doi
040			_dES-MaUEC
050		4	_aQH499 _b.R393 2014
100	1		_aRay Banerjee, Ena. _986920 _0Local
245	1	0	_aPerspectives in Regenerative Medicine _cby Ena Ray Banerjee.
260			_aNew Delhi _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIX, 152 p.) _b79 ilustraciones, 44 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aChapter 1 Stem Cell and its Niche -- Sub-Chapter A. Stem Cell Niche in the Lung -- Sub-Chapter B. Other Stem Cell Niches -- Sub-chapter C. Mesenchymal Stem Cells -- Chapter 2A. Minireview of Stem Cell, Study Models & Effect of Trace Elements -- Chapter 3. Use of Stem Cells for Drug Screening -- Chapter4. Tissue Differentiation of ESC into Lung Cells & Functional Validation -- Chapter 5. Validation of Lung Stem Cell Niche -- Chapter 6. Model Organisms in Science & Research -- Chapter 7. Models for Studies in Regenerative Medicine -- Chapter 8Â{u04AF}le of Progenitors in Pulmonary Fibrosis and Asthma -- Chapter 9. Some Concepts in Studies of Kidney Regeneration -- Chapter 10. Ethics in Stem Cell Research -- Post Script.
520			_aThe information given in this book tries to capture the essence of the sheer dynamicity of the cell along with useful tips on how to address critical rate limiting steps in the process of exploration and investigation of its capacity to regenerate, rebuild and replenish from within. The definitions of stem cells, stemness, and the niche concept continue to undergo revisions. In adult vertebrates, hematopoietic and some non-hematopoietic progenitors are synthesized within specialized niches of bone marrow. They migrate to designated tissues, and are either trans-differentiated or become quiescent and settle down. These form the stem cell niche reservoir in all tissues. Not only the primary hematopoietic tissue but all organs and tissues are also capable of generating progenitors which are either synthesized from these migrants or are direct recruits from other tissues. In the niches, the cells settle down and await their turn to either make more clones like themselves or differentiate and mobilize in an exigency. Thus progenitors are important reserves, to be multiplied and deployed or travel as important message bearing molecules via blood as circulating progenitors which can home to their allocated destinations. Upon reaching, specific integrins and selectins help them “dockâ€{u086E}d “portâ€{u086E}d they may be reprogrammed to induce further differentiation and help repopulate the denuded tissue. In pulmonary fibrosis and asthma, progenitors from both systemic circulation and local stem cell niches have been found to participate in the myriad ramifications of repair, replacement and regeneration of lost or diseased tissue. Whether they are lung specific or global in origin and role remain to be explored. Research tools, fundamental concepts, techniques, methodologies and standard operating protocols and animal models and human extrapolations, have been discussed in a concise way along with detailed description and discussion on the appropriate rationale to introduce the subject to the casual reader and provide valuable tactical information to the specialist in Regenerative Medicine. I sincerely hope you enjoy the work and appreciate the hard work that has gone into designing and executing elegant experiments by many researchers in the field. The branch is multi-disciplinary and I hope that the readers will not be limited to biologists alone. Â{u0000}
650		7	_2embne _9148273 _aRegeneración (Biología)
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-81-322-2053-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b1284391x _b10-10-17 _c23-02-15
942			_2lcc _cLE
945			_aQH499 .R393 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11556821 _z06-04-17
988			_aEBSPRINGER
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