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008			150127s2014 gw | s |||| 0|eng d
020			_a9783319119854
024	7		_a10.1007/978-3-319-11985-4 _2doi
040			_dES-MaUEC
050		4	_aQP623.5 _bP377 2014
100	1		_aPassos, Geraldo A. _eeditor literario _986874 _0Local
245	1	0	_aTranscriptomics in Health and Disease _cedited by Geraldo A. Passos.
260			_aCham, Switzerland _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XVII, 344 p.) _b44 ilustraciones, 34 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart 1: Basic Principles of the Transcriptome and its Analysis -- What is the Transcriptome and how it is Evaluated? -- Transcriptome Analysis Throughout RNA-seq -- Identification of Biomarkers and Expression Signatures -- Methods for Gene Co-expression Network Visualization and Analysis -- Posttranscriptional Control During Stem Cells Differentiation -- Transcriptome Analysis During Normal Human Mesenchymal Stem Cell Differentiation -- Part II: Transcriptome in Disease -- Thymus Gene Co-expression Networks: A comparative study in children with and without down syndrome -- Transcriptome Profiling in Autoimmune Diseases -- Expression of DNA Repair and Response to Oxidative Stress Genes in Diabetes Mellitus -- MicroRNAs in Cancer -- Transcriptome Profiling in Chronic Inflammatory Diseases of the Musculoskeletal System -- Transcriptome Profiling in Experimental Inflammatory Arthritis -- Transcriptome in Human Mycoses -- Transcriptomics of the Host-pathogen Interaction in Paracoccidioidomycosis -- Dissecting Tuberculosis through Transcriptomic Studies -- Understanding chagas Disease by Genome and Transcriptome Exploration -- Expression Tests in Actual Clinical Practice: How medically useful is the transcriptome? -- Conclusions -- Index.
520			_aAfter sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it. The authors discuss the concept and use of gene expression signatures and transcriptional biomarkers in normal development and diseased tissues and organs. As the transcriptome changes depending on the pathology, there is also a focus on the variations in the gene expression in different diseases such as autoimmune, inflammation, cancer and infections. This book should be very useful for researchers in molecular biology focusing on gene expression, human genetics, immunology, and genomics.
650		7	_2embne _9144940 _aARN
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-11985-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12843659 _b10-10-17 _c23-02-15
942			_2lcc _cLE
945			_aQP623.5 P377 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11556560 _z06-04-17
988			_aEBSPRINGER
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