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008			141205s2014 xxu| s |||| 0|eng d
020			_a9781493920952
024	7		_a10.1007/978-1-4939-2095-2 _2doi
040			_cES-MaUEC
050		4	_aQP91 _b.C674 2014
082	0	4	_a610
100	1		_aCorey, Seth Joel _eeditor. _0Local _986835
245	1	2	_aA Systems Biology Approach to Blood _cedited by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (IX, 403 p.) _b73 ilustraciones, 52 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v844
505	0		_aPart I: Basic Components -- Systems Hematology:Â{u006E} Introduction -- Quantification and Modeling of Stem Cell - Niche Interaction -- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling -- Erythropoiesis: From Molecular Pathways to System Properties -- Systems Biology of Megakaryocytes -- Systems Biology of Platelet-Vessel Wall Interactions -- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes -- Part II: Physiological Processes -- Stochasticity and Determinism in Models of Hematopoiesis -- Systems Analysis of Highâ€{u4A32}oughput Data -- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control -- A Systems Biology Approach to Iron Metabolism -- Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis -- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems -- Structure and Function of Platelet Receptors Initiating Blood Clotting -- Part III: Clinical Applications -- Understanding and Treating Cytopenia through Mathematical Modeling -- Drug Resistance -- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models -- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure -- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine -- Part IV: Epilogue -- A Systems Approach to Blood Disorders -- Index.
520			_aThe blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules.Â{u2B2F}ood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells.Â{u8A67}ghly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine.Â{uDBF2}re importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
650	2	7	_aHematología _2embne _9140122
650		7	_aSistemas biológicos _2embne _9403517
700	1		_aKimmel, Marek _eeditor literario _986836 _0Local
700	1		_aLeonard, Joshua N. _eeditor literario _0Local _986837
710	2		_aSpringerLink (Online service) _0Local _9106996
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v844 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-2095-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12843428 _b10-10-17 _c23-02-15
942			_2lcc _cLE
945			_aQP91 .C674 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1155633x _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h2