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007			cr nn 008mamaa
008			141021s2014 xxu| s |||| 0|eng d
020			_a9781493920075
024	7		_a10.1007/978-1-4939-2007-5 _2doi
040			_dES-MaUEC
050		4	_aQP321 _b.R355 2014
100	1		_aRall, Jack A. _986834 _0Local
245	1	0	_aMechanism of Muscular Contraction _cby Jack A. Rall.
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIII, 471 p.) _b179 ilustraciones, 34 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aPerspectives in Physiology
505	0		_aSetting the Stage: Myosin, Actin, Actomyosin and ATP -- Birth of the Sliding Filament Model of Muscular Contraction: Proposal -- Glory Days: Establishment of the Sliding Filament Model of Muscular Contraction in the 1950s and 1960s -- Excitation-Contraction Coupling and the Role of Calcium in Contraction and Relaxation in the 1950s and 1960s -- Mechanics and Energetics of Muscular Contraction: Before Sliding Filaments and into the Modern Era -- 1972 Cold Spring Harbor Symposia On Quantitative Biology: The Mechanism of Muscle Contraction. Problem Solved?? -- Endosarcomeric and Exosarcomeric Cytoskeleton: Emergence of Cell and Molecular Biology in the Muscle Field -- Excitation-contraction Coupling and Regulation of Contraction in Skeletal Muscle: The Modern Synthesis -- Molecular Mechanism of Force Production: From the Difficult 1980s to the Supercharged 1990s and Beyond -- Index.
520			_aFundamental discoveries in the 1950s relating to the mechanism of muscle contraction fueled an explosion of knowledge in the latter half of the 20th century. This book traces in depth the evolution of ideas from the 1950s into the 21st century. In a scholarly yet highly readable monograph, the book describes the history on which our current understanding of muscle function is based. This is the most comprehensive study and first book-length treatment of the muscle field in over forty years. In order to provide perspective into the thinking about an issue at the time of its discovery, often the investigators describe in their own words an important result or conclusion as it appeared in an original paper. Numerous figures from the original papers are included in order to allow the reader to see the data that led to important conclusions. More than a history of experimental facts, the book describes backgrounds of many of the key investigators to allow a deeper insight into their motivations and approach to science. Controversies in the muscle field are discussed along with some missed opportunities and false trails. An amazing variety of experimental techniques have been brought to bear on the investigation of the mechanism of muscular contraction. Background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. The book is organized into nine chapters with over 170 illustrations and 1,200 references. The book provides insight into scientific thought and forms a framework for future enquiry into muscle function. The author, an emeritus professor in the department of physiology and cell biology at Ohio State University, has been a contributor to research in the muscle field for over forty years.
650		7	_2embne _9210898 _aMúsculos _xFisiología
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-2007-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12843416 _b10-10-17 _c23-02-15
942			_2lcc _cLE
945			_aQP321 .R355 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11556328 _z06-04-17
988			_aEBSPRINGER
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