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008			141020s2014 xxu| s |||| 0|eng d
020			_a9781493916832
024	7		_a10.1007/978-1-4939-1683-2 _2doi
040			_dES-MaUEC
050		4	_aQH442 _b.C455 2014
100	1		_aChi, Jen-Tsan Ashley _eeditor literario _0Local _986829
245	1	0	_aMolecular Genetics of Dysregulated pH Homeostasis _cedited by Jen-Tsan Ashley Chi.
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 160 p.) _b16 ilustraciones, 12 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aMolecular Genetics of Acid Sensing and Response -- Part I: Sensing Acidity -- The molecular mechanism of cellular sensing of acidity -- The Molecular Basis of Sour Sensing in Mammals -- Function and Signaling of the pH-sensing G protein-coupled receptors in physiology and diseases -- Part II: Response to Acidity -- The MondoA-TXNIP checkpoint couples the acidic tumor microenvironment to cell metabolism -- Regulation of Renal Glutamine Metabolisms during Metabolic Acidosis -- Extracellular acidosis and cancer -- The genomic analysis of cellular responses and adaptions to extracellular acidosis -- Index.
520			_aMost biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological function at every level, including protein folding, enzymatic activities and proliferation, and cell death. Therefore, maintaining the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in scientific literature and in medical textbooks.Âȯwever, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events, and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases including cancer, stroke, myocardial infarction, diabetes, and renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and respond to acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanisms and cellular responses to pH alterations in both physiological (taste, pain) and pathological (ischemia and cancers) settings. Furthermore, the authors present a broad spectrum of investigative approaches to cellular response to acidosis in a wide variety of human diseases.
650		7	_2embne _9141520 _aIngeniería genética
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1683-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12843386 _b10-10-17 _c23-02-15
942			_2lcc _cLE
945			_aQH442 .C455 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11556298 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0