000			03923nam a22003735i 4500
999			_c77856 _d77856 _x1
001			77856
003			ES-MaUEC
005			20230207040247.0
007			cr nn 008mamaa
008			141011s2014 xxu| s |||| 0|eng d
020			_a9781493915194
024	7		_a10.1007/978-1-4939-1519-4 _2doi
040			_dES-MaUEC
050		4	_aRS201.C64 _bT566 2014
100	1		_aTimmins, Peter. _eeditor literario _986819 _0Local
245	1	0	_aHydrophilic Matrix Tablets for Oral Controlled Release _cedited by Peter Timmins, Samuel R. Pygall, Colin D. Melia.
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (IX, 326 p.) _b102 ilustraciones, 37 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAAPS Advances in the Pharmaceutical Sciences Series _x2210-7371 _v16
505	0		_a1 Hydrophilic Matrix Dosage Forms: Definitions, General Attributes and the Evolution of Clinical Utilization -- 2 Design and Evaluation of Hydroxypropyl Methylcellulose Matrix Tablets for Oral Controlled Release: a Historical Perspective -- 3 An Industrial Perspective on Hydrophilic Matrix Tablets based on Hyproxypropyl Methylcellulose (Hypromellose) -- 4 Natural Polysaccharides in Hydrophilic Matrices -- 5 Applications of Polyethylene Oxide (POLYOX) in Hydrophilic Matrices -- 6 A Formulation Development Perspective on Critical Interactions Affecting the Performance of Hydrophilic Matrix Tablets -- 7 In vitro Physical and Imaging Techniques to Evaluate Drug Release Mechanisms from Hydrophilic Matrix Tablets -- 8 Physiologically-Based Pharmacokinetic Modelling in the Development and Evaluation of Hydrophilic Matrix Tablets -- 9 Approaches to Rapid In Vivo Optimization of Hydrophilic Matrix Tablets -- 10 Extrusion: an Enabling Technology for Controlled Release Hydrophilic Matrix Systems -- 11 Microenvironmental pH Control and Mixed Polymer Approaches to Optimize Drug Delivery with Hydrophilic Matrix Tablets -- 12 Evolving Biopharmaceutics Perspectives for Hydrophilic Matrix Tablets: Dosage Form-Food Interactions and Dosage Form Gastrointestinal Tract Interactions.
520			_aThis detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues.Â{u0537}elve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.
650		7	_2embne _9173033 _aMedicamentos _xAdministración
700	1		_aPygall, Samuel R _eeditor literario _986820 _0Local
700	1		_aMelia, Colin D _eeditor literario _986821 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1519-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12843350 _b10-10-17 _c23-02-15
942			_2lcc _cLE
945			_aRS201.C64 T566 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11556262 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0