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| 003 | ES-MaUEC | ||
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| 008 | 140908s2014 ne | s |||| 0|eng d | ||
| 020 | _a9789401792110 | ||
| 040 | _aES-MaUEC | ||
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_aRC268.4 _b.M88 2014 EB |
|
| 245 | 0 | 0 |
_aMutant p53 and MDM2 in Cancer _cedited by Swati Palit Deb, Sumitra Deb |
| 260 |
_aDordrecht, Netherlands _bSpringer _c2014 |
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| 300 | _a1 recurso en línea (VIII, 373 p.) 38 il., 36 il. col. | ||
| 336 |
_aTexto (visual) _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
||
| 338 |
_arecurso electrónico _bcr _2rdacarrier |
||
| 490 | 1 |
_aSubcellular Biochemistry _x0306-0225 _v85 |
|
| 520 | _aThis book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer, and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer, and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels. | ||
| 942 |
_2lcc _cLE |
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| 988 | _aEBOOK, EBSPRINGER | ||
| 650 | 7 |
_aCáncer _xAspectos genéticos _9273952 _0comprobar BNE19990911214 _2embne |
|
| 700 | 1 |
_aDeb, Swati Palit _eeditor literario _986390 _0Local |
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| 700 | 1 |
_aDeb, Sumitra _eeditor literario _986391 _0Local |
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| 830 | 0 |
_aSubcellular Biochemistry _x0306-0225 _v85 _9133378 |
|
| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-9211-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 901 | _ai9789401792110 | ||
| 907 |
_a.b12825803 _b10-10-17 _c01-10-14 |
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