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008			140714s2014 ne | s |||| 0|eng d
020			_a9789401791533
024	7		_a10.1007/978-94-017-9153-3 _2doi
040			_dES-MaUEC
050		4	_aQP552.I55 _bG855 2014
100	1		_aGullberg, Donald _eeditor literario _0Local _986386
245	1	0	_aI Domain Integrins _cedited by Donald Gullberg.
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIV, 179 p.) _b50 ilustraciones, 32 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v819
505	0		_aPreface -- 1 Evolution of integrin I domains -- 2 Integrin a1b1 -- 3 Integrin a2b1 -- 4 Integrin a10b1- a collagen receptor critical in skeletal development -- 5 Integrin a11b1 â€{u0860}major collagen receptor on fibroblastic cells -- 6 Regulation of integrin activity by phosphorylation -- 7 Integrin aEb7:molecular features and functional significance in the immune system -- 8 Structural aspects of integrins -- 9 Integrin recognition motifs in the human collagens -- 10 Cellular signalling by collagen-binding integrins -- 11 The therapeutic potential of I-domain integrins -- Index.
520			_aThe integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
650		7	_2embne _aProteínas _9139861
650		7	_2embne _aAminoácidos _9138424
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-9153-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12825773 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP552.I55 G855 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11554988 _z06-04-17
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