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008			140624s2014 ne | s |||| 0|eng d
020			_a9789401790505
024	7		_a10.1007/978-94-017-9050-5 _2doi
040			_aES-MaUEC
050		4	_aQP801.R47 _bB56 2014 EB
082	0	4	_a610
700	1		_aAsson-Batres, Mary Ann _eeditor literario. _0Local _0http://id.loc.gov/authorities/names/nb2014018463 _1http://viaf.org/viaf/310619941 _986377
245	0	4	_aThe Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level _cedited by Mary Ann Asson-Batres, Cécile Rochette-Egly.
264		1	_aDordrecht, Netherlands, Netherlands _bSpringer _c2014
300			_a1 recurso en línea (VIII, 230 páginas) _b46 ilustraciones, 44 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSubcellular Biochemistry _x0306-0225 _v70
505	0		_aForward -- History of Retinoic Acid Receptors -- Architecture of DNA Bound RAR Heterodimers -- Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange -- Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling -- RXRs: Collegial Partners -- Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected- The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes -- RARs and micro RNAs -- Integrative genomics to dissect retinoids functions -- Complexity of the RARâ€{uD964}diated Transcriptional Regulatory Programs -- Index.
520			_aA role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
650		7	_aRetinoides _9157930 _2embne
700	1		_aRochette-Egly, Cécile _eeditor literario _986378 _0Local
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-9050-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12825712 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aR-RZ EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11554927 _z06-04-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
988			_aEbook_one2one
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ef _feng _gne _h4
999			_c76953 _d76953 _x1