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008			140721s2014 ne | s |||| 0|eng d
020			_a9789401789080
024	7		_a10.1007/978-94-017-8908-0 _2doi
040			_dES-MaUEC
050		4	_aQR74 _b.C644 2014
100	1		_aCohen, G. N. _986352 _0Local
245	1	0	_aMicrobial Biochemistry _cby G. N. Cohen.
250			_a3rd ed. 2014.
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XXVIII, 611 p.) _b314 ilustraciones, 9 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aBacterial growth -- The outer membrane of Gram-negative bacteria and the cytoplasmic membrane -- Peptidoglycan synthesis and cell division -- Cellular permeability -- Allosteric enzymes -- Glycolysis, gluconeogenesis, glycogen and cellulose biosynthesis -- The pentose phosphate and Entner-Doudoroff pathways -- The tricarboxylic acid cycle and the glyoxylate bypass -- ATP-generating processes. Respiration and Fermentation -- Biosynthesis of lipids -- Iron-sulfur proteins -- The Archaea -- Methanogens and methylotrophs -- Enzyme induction in catabolic systems -- Transcription. RNA polymerase -- Negative regulation -- Enzyme repression in anabolic pathways -- Positive regulation -- The Ribosomes, Translation, Chaperones and Chaperonins -- The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases -- Attenuation -- Regulation by RNAs and Riboswitches -- The biological fixation of nitrogen -- How biosynthetic pathways have been established -- The aspartic acid family of amino acids.-Â{u2967}ulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae -- Other patterns of regulation of the synthesis of amino acids of the aspartate family -- Biosynthesis of the amino acids of the glutamic acid family and its regulation -- Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid -- Selenocysteine and selenoproteins -- Biosynthesis of aromatic amino acids and its regulation -- The biosynthesis of histidine and its regulation -- The biosynthesis of nucleotides -- The biosynthesis of deoxyribonucleotides -- Biosynthesis of some water-soluble vitamins and of their coenzyme forms -- Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones -- Biosynthesis of the tetrapyrrole ring system -- Biosynthesis of cobalamins including vitamin B12 -- Interactions between proteins and DNA -- Evolution of biosynthetic pathways.
520			_aThis book focuses on microbial physiology, biochemistry, and genetics and provides the reader with detailed information on a number of microbial pathways. Insight into microbial biochemistry allows for the formulation of concepts which have turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery which is indispensable for the comprehension of many regulatory mechanisms described throughout the book. The second section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The fifteen chapters after that deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.
650		7	_2embne _aBiología molecular _9139103
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-8908-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b1282561x _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQR74 .C644 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11554824 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gne _h0