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008			140106s2014 ne | s |||| 0|eng d
020			_a9789401780353
024	7		_a10.1007/978-94-017-8035-3 _2doi
050		4	_aRC271.N46 _bR533 2014
100	1		_aRibatti, Domenico. _986304 _0Local
245	1	0	_aAngiogenesis and Anti-Angiogenesis in Hematological Malignancies _cby Domenico Ribatti.
260			_aDordrecht, Netherlands _bSpringer _c2014
300			_a1 recurso en línea (XI, 114 páginas) _b44 ilustraciones, 30 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- Introduction -- Angiogenesis in multiple myeloma -- Angiogenesis in lymphomas -- Angiogenesis in leukemia -- Antiangiogenesis -- Concluding remarks -- References.
520	3		_aIt has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular nicheâ€{uC829}ndicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias, EBSPRINGER,
650		7	_aNeovascularización _0(OCoLC)1035916 _2embne _0 _9164656
650		7	_aInhibidores de la neovascularización _0(OCoLC)1035919 _2embne _0 _9671432
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-8035-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12825311 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gne _h0
945			_aRC271.N46 R533 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11554526 _z06-04-17
999			_c76913 _d76913 _x1