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008			140117s2014 ne | s |||| 0|eng d
020			_a9789400778931
024	7		_a10.1007/978-94-007-7893-1 _2doi
040			_dES-MaUEC
050		4	_aRC924 _b.H357 2014
100	1		_aHalper, Jaroslava _eeditor literario _0Local _986296
245	1	0	_aProgress in Heritable Soft Connective Tissue Diseases _cedited by Jaroslava Halper.
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 245 p.) _b35 ilustraciones, 31 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v802
505	0		_aStructure, physiology and biochemistry of collagens -- Basic components of connective tissues and extracellular matrix -- Proteoglycans and diseases of soft tissues -- Advances in the use of growth factors for treatment of disorders of soft tissues -- Clinical, diagnostic, and therapeutic aspects of the Marfan syndrome -- Loeys-Dietz syndrome -- Connective Tissue Disorders and Cardiovascular Complications: The indomitable role of Transforming Growth Factor-beta signaling -- The Ehlers-Danlos Syndrome -- Ehlersâ€{u486E}los syndrome associated with glycosaminoglycan abnormalities -- Cutis laxa -- Collagen type VI myopathies -- Mouse Models in Tendon and Ligament Research -- Connective tissue disorders in domestic animals.
520			_aThis volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers.Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues.Â{u4A29}s new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.
650		7	_2embne _aTejidos (Biología) _9668849
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-7893-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12825244 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC924 .H357 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11554459 _z06-04-17
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