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020			_a9789400777262
024	7		_a10.1007/978-94-007-7726-2 _2doi
050		4	_aRD651 _b.T86 2014 EB
082	0	4	_a570
245	0	0	_aTumor Dormancy, Quiescence, and Senescence, Volume 2 : _bAging, Cancer, and Noncancer Pathologies _cedited by M.A. Hayat
260			_aDordrecht, Netherlands _bSpringer _c2014
300			_a1 recurso en línea (XXVII, 320 p.) _b49 ilustraciones, 33 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aTumor Dormancy and Cellular Quiescence and Senescence, Aging, Cancer, and Noncancer Pathologies _v2
505	0		_aPreface. I Molecular Mechanisms -- Asymmetric Dimethylarginine Accelerates Cellular Senescence -- Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis -- Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924 -- Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase -- Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction -- Interleukin- 6 induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5 -- A Role for the Nuclear Lamina Shape in Cell Senescence and Aging -- Upregulation of Alpha-2-Macroglobulin in Replicative Senescence -- Elevation of Ceramide in Senescence: Role of Sphingolipid Metabolism -- Molecular Signals Underlying Hair Follicle Morphagenesis and Cutaneous Regeneration -- Role of Chromatin modeling Factor Jun Dimerization Protein 2 (JDP2) in Cellular Senescence -- Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1 -- Mechanisms of Premature Cell Senescence. II Tumor And Cancer -- Nuclear Protein Pirin Negates the Cellular Senescence Barrier Against Cancer Development -- Defects in Chromatin Structure and Diseases -- The Role of Fibrosis in Tumor Progression and the Dormant to Proliferative Switch -- Diagnosis of Branchial Cyst Carcinoma: Role of Stem Cells and Dormancy -- Function of ING Proteins in Cancer and Senescence -- Premalignancy and Cellular Senescence -- Loss of CDH1 Triggers Premature Senescence in Part Via Activation of Both the RB/E2F1 and the Claspin/CHK1/P53 Tumor Suppressor Pathways -- Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression -- Senescence Escape in Melanoma: Role of Spleen Tyrosine Kinase SYK -- Micrometastatic Cancer Cells: Role of Tumor Dormancy in Non-Small Cell Lung Cancer. III Quiescent Cd4+ T Cells Inhibit Multiples Stages Of Hiv Infection Stem Cells And Cancer Stem Cells -- Senescent-Derived Pluripotent Stem Cells are able to Redifferentiate into Fully Rejuvenated Cells -- The Transcription Factor Gata2 Regulates Quiescence in Haematopoietic Stem and Progenitor Cells -- Dormancy and Recurrence of Cancer Stem Cells in Bone: Role of Bone Morphogenetic Proteins -- Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior and its Potential Therapeutic Implications -- Index
520	3		_aIn this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aCáncer _xCirugía _0comprobar BNE19901197941 _2embne _9175031
700	1		_aHayat, M. A. _eeditor literario _0Local _986068
830		0	_aTumor Dormancy and Cellular Quiescence and Senescence, Aging, Cancer, and Noncancer Pathologies _v2 _9133396
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-7726-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9789400777262
907			_a.b12825153 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b02-10-17 _cm _dz _ek _feng _gne _h0
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