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008			140127s2013 ne | s |||| 0|eng d
020			_a9789400775008
024	7		_a10.1007/978-94-007-7500-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP532 _b2013 EB
245	0	0	_aInterrelations between Essential Metal Ions and Human Diseases _cedited by Astrid Sigel, Helmut Sigel, Roland K.O. Sigel.
264		1	_aDordrecht _bSpringer Netherlands _c2013.
300			_a1 recurso en línea (XXXVII, 573 p.) : _b103 ilustraciones, 28 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aMetal Ions in Life Sciences _x1559-0836 _v13
505	0		_aMetal Ions and Infectious Diseases. An Overview from the Clinic -- Sodium and Potassium in Health and Disease -- Magnesium in Health and Disease -- Calcium in Health and Disease -- Vanadium. Its Role for Humans -- Chromium: Is It Essential, Pharmacologically Relevant or Toxic?- Manganese in Health and Disease -- Iron: Effect of Deficiency and Overload -- Cobalt: Its Role in Health and Disease -- Nickel and Human Health -- Copper: Effects of Deficiency and Overload -- Zinc and Human Disease -- Molybdenum in Human Health and Disease -- Silicon: The Health Benefits of a Metalloid -- Arsenic. Can this Toxic Metalloid Sustain Life? -- Selenium. Role of the Essential Metalloid in Health.
520			_aMILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.
988			_aEBOOK, EBSPRINGER
650		7	_aMetales _xEfectos fisiológicos _2embne _9138327
650		7	_aIones _xEfectos fisiológicos _2embne _9676271
700	1		_aSigel, Helmut _eeditor _986260
700	1		_aSigel, Roland K.O _eeditor _986261
700	1		_aSigel, Astrid. _eeditor _986259
710	2		_aSpringerLink (Online service) _0Local _9106996
830		0	_aMetal Ions in Life Sciences _x1559-0836 _v13 _9133425 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-7500-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_dz _eo _b10/2020 _zSI