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003			ES-MaUEC
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007			cr nn 008mamaa
008			131104s2014 ne | s |||| 0|eng d
020			_a9789400774292
024	7		_a10.1007/978-94-007-7429-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552.M44 _b2014 EB
100	1		_aFioroni, Marco _986235
245	1	0	_aß-barrel Channel Proteins as Tools in Nanotechnology : _bBiology, Basic Science and Advanced Applications _cMarco Fioroni, Tamara Dworeck, Francisco Rodriguez-Ropero.
264		1	_aDordrecht _bSpringer Netherlands _c2014.
300			_a1 recurso en línea (XII, 168 p.) : _b45 ilustraciones, 29 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v794
505	0		_aPreface -- Introduction -- Biology -- Biophysical Characterization -- Theoretical Considerations and Computational Tools -- Biotechnology -- Technological Applications -- Final Considerations. Index.
520			_ab-barrel outer membrane channel proteins (OMP) have great potential as robust and flexible models or components in nanotechnology. Over the last decade biotechnological techniques allowed to expand the natural characteristics of OMPs by modifying their geometry and properties without affecting the overall protein structure and stability. The present book is oriented towards a broad group of readers including graduate students and advanced researchers. The b-barrel structure serviceability for the nano-material design will be its chief topic giving a general introduction to the field of OMP based nano-component development as well as the state of the art of the involved research. On the example of the E. coli FhuA the transformation of an OMP into a tailored nano-channel to be adapted to a non-biological synthetic (i.e. polymer) environment, rendering it competitive with artificial non-biological nano-pores will be outlined specifically the design of a set of protein nano-channels with tailored geometry (diameter, length), conductance and functionality will be reported as a case study. In order to make this book a valuable source of information for both biotechnologists and other scientists interested in bio-nanotechnology an overview of the different steps involved in the nano-channel protein design and production will be reported. The scientific strategy from concept design, theoretical considerations, genetic engineering and large scale production, to system assembly and biophysical characterization with an overview on technological applications including membrane/polymersome technology, will be described.
988			_aEBOOK, EBSPRINGER
650		7	_9671893 _aProteínas de membranas _2embne
650		7	_aNanotecnología _2embne _9158453
700	1		_aDworeck, Tamara _986236
700	1		_aRodriguez-Ropero, Francisco. _986237
710	2		_aSpringerLink (Online service) _0Local _9106996
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v794 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-7429-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2020 _dz _eo