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008			131121s2014 ne | s |||| 0|eng d
020			_a9789400773059
024	7		_a10.1007/978-94-007-7305-9 _2doi
040			_aES-MaUEC _dES-MaUEC
050		4	_aQL368.E95 _bS268 2014
100	1		_aSantos, André _eeditor literario _986217 _0Local
245	1	0	_aProteins and Proteomics of Leishmania and Trypanosoma _cedited by André L.S. Santos, Marta H. Branquinha, Claudia M. D'Avila-Levy, Lucimar F. Kneipp, Cátia L Sodré
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2014
300			_a1 recurso en línea (X, 381 p.) _b55 ilustraciones, 37 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSubcellular Biochemistry _x0306-0225 _v74
505	0		_aPreface -- Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure -- Selection of Molecular Targets for Drug Development against Trypanosomatids -- A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development -- Arginase in Leishmania -- The heat shock proteins of Trypanosoma cruzi -- The Gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms -- The Gp85 Surface Glycoproteins from Trypanosoma cruzi -- Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications -- Surface Topology Evolution of Trypanosoma Trans-Sialidase -- Ecto-Nucleotidases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites -- Gp63 Function in the Interaction of Trypanosomatids with the Invertebrate Host â€ơcts and Prospects -- Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis -- The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biological Applications for Drug Target Discovery -- Proteomics advances in the study of Leishmania parasites and leishmaniasis -- Towards the Phosphoproteome of Trypanosomatids. Index.
520			_aThis book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatidsâ€{u09E5}nera are etiological agents of leishmaniasis, Chagasâ€{u0929}sease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteome of Leishmania and Trypanosomaâ€{u096E}compasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
650		7	_2embne _aProteínas _9139861
700	1		_aBranquinha, Marta H. _eeditor literario _0Local _986218
700	1		_aD'Avila-Levy, Claudia M. _eeditor literario _986219 _0Local
700	1		_aKneipp, Lucimar F. _eeditor literario _0Local _986220
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-7305-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12824811 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQL368.E95 S268 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11554022 _z06-04-17
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