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008			130522s2013 ne | s |||| 0|eng d
020			_a9789400766211
024	7		_a10.1007/978-94-007-6621-1 _2doi
050		4	_aQH588.S83 _bT73 2013 EB
082	0	4	_a610
245	0	0	_aTranscriptional and translational regulation of stem cells _cedited by Gary Hime, Helen Abud
260			_aDordrecht _bSpringer Netherland _c2013
300			_a1 recurso en línea (X, 371 páginas) _b61 ilustraciones, 53 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v786
505	0		_aThe stem cell state -- Induction of pluripotency -- Germline stem cells and their regulation in the nematode Caenorhabditis elegans -- Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny -- Stem cells in the Drosophila digestive system -- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System -- Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells -- Transcriptional Regulation and Specification of Neural Stem Cells -- Transcriptional Control of Epidermal Stem Cells -- Regulation of intestinal stem cells by Wnt and Notch signalling -- Transcriptional regulation of haematopoietic stem cells -- Regulation of mesenchymal stem cell differentiation -- Molecular families implicated in stem cell regulation -- The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations -- JAK-STAT signalling in stem cells -- Myc in Stem Cell Behaviour: insights from Drosophila -- The Role of Nuclear Receptors in Embryonic Stem Cells -- Epigenetic regulation of stem cells.-Regulation of stem cell populations by microRNAs -- Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches
520			_aStem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury. In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced. Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of differentiation could disrupt tissue homeostasis or repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of research in these rapidly evolving areas of stem cell biology to the student, educator or researche
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aCélulas madre _0comprobar BNE20022110396 _2embne _9160528
650		7	_aCitología _0comprobar BNE19900972907 _2embne _9139477
650	2	4	_9162368 _aBiología del desarrollo _0LocalV
700	1		_aHime, Gary _eeditor literario _986151 _0Local
700	1		_aAbud, Helen _eeditor literario _986152 _0Local
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v786 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-6621-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9789400766211
907			_a.b12824410 _b07-11-17 _c01-10-14
998			_am _a_alco _a_vill _b07-11-17 _cm _dz _eb _feng _gne _h0
945			_aQH588 .S83 T73 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11553625 _z06-04-17
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