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003			ES-MaUEC
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008			130618s2013 ne | s |||| 0|eng d
020			_a9789400763319
024	7		_a10.1007/978-94-007-6331-9 _2doi
040			_dES-MaUEC
050		4	_aQP517.C45 _bC374 2013
100	1		_aCapelluto, Daniel G. S. _eeditor literario _0Local _986121
245	1	0	_aLipid-mediated Protein Signaling _cedited by Daniel G.S. Capelluto.
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XIII, 219 p.) _b44 ilustraciones, 28 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v991
505	0		_aSphingomyelin and its role in cellular signaling -- The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains -- The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition -- Phosphoinositides and PDZ Domain Scaffolds -- PtdIns(4)P signalling and recognition systems -- PtdIns(4,5)P2-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism -- Role of Phosphatidylinositol 3,4,5-trisphosphate in Cell Signaling -- The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling -- Phosphatidic Acid-Mediated Signaling -- Phosphatidylserine-mediated cellular signaling -- Cardiolipin-mediated cellular signaling.
520			_aLipids are no longer seen as molecules that only provide membrane structure and organization. Â{u4D65}e to their amphipathic nature, lipids are localized both on the surface and internally in membranes in the cell, and at these locations, trigger signaling pathways by interacting with soluble proteins, typically through lipid-interacting domains and motifs. More importantly, interconversion of lipid species in these compartments is fundamental, not only by sustaining signaling but also by contributing to signaling pathways that link protein receptors with intracellular effectors. With contributions from eleven leading research teams, this book updates the most recent findings associated with lipid-mediated cell signaling in mammals and plants. Contributors give comprehensive overviews of the physiological role of sphingolipids and phospholipids and how they undergo synthesis and turnover. Emphasis on the structural aspects of protein-lipid interactions is compiled in several chapters with great detail, whereas fully described mechanisms of lipid-mediated membrane targeting and insertion are considered in others. Authors also discuss models and techniques used to characterize lipid-mediated membrane binding of proteins. In addition, several chapters highlight the correlation of abnormal intracellular levels of lipids with human diseases, thus, making this book a valuable resource for biochemists, biophysicists, cell biologists, and clinical scientists with interest in lipid-mediated signaling pathways.
650		7	_9689361 _aTransducción de la señal celular _2embne
650		7	_9139861 _aProteínas _2embne
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-6331-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12824203 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP517.C45 C374 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11553418 _z06-04-17
988			_aEBSPRINGER
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