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001			76781
003			ES-MaUEC
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007			cr nn 008mamaa
008			130321s2013 ne | s |||| 0|eng d
020			_a9789400759404
024	7		_a10.1007/978-94-007-5940-4 _2doi
040			_dES-MaUEC
050		4	_aQP551 _b.D684 2013
100	1		_aDougan, David A. _eeditor literario _986100 _0Local
245	1	0	_aRegulated Proteolysis in Microorganisms _cedited by David A. Dougan.
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XIV, 333 p.) _b65 ilustraciones, 62 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSubcellular Biochemistry _x0306-0225 _v66
505	0		_aMachines of destruction - AAA+ proteases and the adaptors that control them -- The AAA+ protease Lon -- FtsH protease-mediated regulation of various cellular functions -- Regulated proteolysis in Bacillus subtilis -- Regulation of stress response pathways in Escherichia coli by proteolysis -- Regulation of the SigmaE stress response -- Pathogenic bacteria: protein degradation and virulence -- Roles of Cdc48 in regulated protein degradation in yeast -- The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis & activity control -- PUPylation and Mycobacteria -- Archea proteasomes and SAMPylation.
520			_aThis book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Bakerâ€{u3839}east Saccharomyces cerevisiae).  For many years, intracellular protein degradation was almost exclusively thought of as a non-selective mechanism to recycle amino acids and remove trash from the cell. The contemporary view however, is that protein degradation is a highly selective process that plays a key role in a number of important cellular processes. Not only does it contribute to the maintenance of protein homeostasis (proteostasis) through the direct recognition and removal of damaged proteins, but it also regulates the cells response to a variety of environmental stress signals. Regulatory proteolysis also plays an important role in virulence of pathogenic bacteria, and “fitnessâ€{u0BE6} eukaryotic organelles. This book focuses on the central players in these diverse cellular processes â€{u0D28}e AAA+ proteases â€{u086E}d examines how these machines achieve their exquisite specificity. It also highlights the various mechanisms microorganisms use to post-translationally modify their proteins, as a means to regulate protein levels and hence cell physiology.  Â{u04A5}gulated proteolysis in microorganisms is a must read for researchers working on protein homeostasis, stress response pathways and virulence. It provides a detailed overview of the components and signals that contribute to the metabolic stability of a protein in various microorganisms. As such, it also forms a useful resource for researchers in biotechnology. The book is essential reading for senior undergraduate and postgraduate students, studying all areas of protein science including protein chemistry, biochemistry, molecular biology, microbiology and biotechnology.  Key features and content: ·Â{u2802}Â{u2802}Â{u2802}Â{u2802}Â{u2820} Molecular mechanism of action of AAA+ proteases ·Â{u2802}Â{u2802}Â{u2802}Â{u2802}Â{u2820} Control of substrate specificity by adaptor proteins ·Â{u2802}Â{u2802}Â{u2802}Â{u2802}Â{u2820} Post-translational tagging of proteins as a means to control their metabolic stability (SsrA, Ubiquitlyation, PUPylation and SAMPylation) ·Â{u2802}Â{u2802}Â{u2802}Â{u2802}Â{u2820} Regulation of stress response pathways by proteolysis ·Â{u2802}Â{u2802}Â{u2802}Â{u2802}Â{u2820} Regulated degradation and virulence ·Â{u2802}Â{u2802}Â{u2802}Â{u2802}Â{u2820} Protein degradation within mitochondria
650		7	_2embne _aProteínas _9139861
650		7	_2embne _aAminoácidos _9138424
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-5940-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12823995 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP551 .D684 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11553200 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gne _h0