000			02988nam a22003495i 4500
999			_c76775 _d76775
001			76775
003			ES-MaUEC
005			20230208112216.0
007			cr nn 008mamaa
008			130217s2013 ne | s |||| 0|eng d
020			_a9789400758810
024	7		_a10.1007/978-94-007-5881-0 _2doi
040			_dES-MaUEC
050		4	_aQP671.C83 _bD493 2013
100	1		_aDey, Aparajita _eeditor literario _0Local _986091
245	1	0	_aCytochrome P450 2E1 : _bIts Role in Disease and Drug Metabolism _cedited by Aparajita Dey
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XVI, 256 p.) _b35 ilustraciones, 5 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSubcellular Biochemistry _x0306-0225 _v67
505	0		_aCytochrome P450 2E1 and its clinical aspects -- Nrf2 and antioxidant defense against CYP2E1 toxicity -- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis -- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome -- Relevance of CYP2E1 to non-alcoholic fatty liver disease -- CYP2E1-catalyzed alcohol metabolism -- CYP2E1, oxidative stress, post-translational modifications andÂ{u0B29}pid metabolism -- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.
520			_aThe book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
650		7	_2embne _aBioquímica _9138639
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-5881-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12823934 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP671.C83 D493 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11553145 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gne _h0