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008			120731s2013 ne a s 001 0 eng d
020			_a9789400747166
024	7		_a10.1007/978-94-007-4716-6 _2doi
050		4	_aQP601 _b.S45 2013 EB
082	0	4	_a610
100	1		_aSeidler, Norbert W. _0no2012119436 _948494
245	1	0	_aGAPDH: Biological Properties and Diversity _cby Norbert W. Seidler
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XIV, 295 p.) _b96 ilustraciones, 8 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v985
520			_aGAPDH (glyceraldehyde 3-phosphate dehydrogenase) is more than just a glycolytic enzyme. An unprecedented amount of literature demonstrates that GAPDH has an astounding multiplicity of function. This diversity is not simply due to cell compartmentation (i.e. redistributing glycolytic energy to where it is needed), although this feature is undoubtedly important and discussed in the book. GAPDH integrates glycolysis with other cellular processes. This concept of integration cannot be understated. But, there is more. GAPDH actively participates in numerous non-glycolytic cellular events that fall into very broad categories including the cell infrastructure and the transmission of genetic information. Some of GAPDH's biological properties are completely non-intuitive given the current undergraduate textbook understanding of this glycolytic enzyme. For example, GAPDH binds to select phospholipids and catalyzes organelle biogenesis. It has fusogenic properties, enabling it to be actively involved in nuclear envelop reassembly, autophagy and membrane trafficking. Human macrophages exhibit surface-localized GAPDH with receptor function. As scientists, we are trained to consider GAPDH as a soluble cytosolic dehydrogenase enzyme. The literature observations - as described in this book - tell us something quite different. Besides oxidoreductase activity, GAPDH exhibits peroxidase, uracil DNA glycosylase, nitrosylase, mono-ADP-ribosylase, esterase and phosphotransferase activity. GAPDH binds membrane transport proteins, G-proteins, poly-nucleotides, adenines, specific lipids, select carbohydrates, cytoskeletal proteins, nuclear import and export proteins, diverse ATPases, molecular chaperones and other molecules.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aEnzimas _0comprobar BNE19900962355 _2embne _9138640
650		7	_aBioquímica _0comprobar BNE19900962333 _2embne _9138639
650		7	_aMetabolismo _0comprobar BNE19900962300 _2embne _9138638
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-4716-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9789400747166
907			_a.b12823624 _b21-10-17 _c01-10-14
998			_am _a_alco _a_vill _b20-10-17 _cm _dz _ei _feng _gne _h0
945			_aQP601 .S45 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11552839 _z06-04-17
999			_c76744 _d76744 _x1