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008			120813s2013 ne a s 001 0 eng d
020			_a9789400745964
024	7		_a10.1007/978-94-007-4596-4 _2doi
040			_aES-MaUEC
050		4	_aQP552.G16 _bS77 2013 EB
082	0	4	_a610
100	1		_aStrasser, Andrea _0nb2012023916 _948464
245	1	0	_aModelling of GPCRs : _bA Practical Handbook _cby Andrea Strasser, Hans-Joachim Wittmann
260			_aDordrecht, Netherlands _bSpringer International Publishing _c2013
300			_a1 recurso en línea (X, 218 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- 1.Introduction -- 2.G Protein Coupled Receptors -- 3.Sequence alignment and homology modelling -- 4.Construction of ligands -- 5.Lipids -- 6.Minimization and molecular dynamics.-7.Calculation of Gibbs energy of salvation -- 8.Special topics in GPCR research -- 9.Force fields -- 10.Thermodynamics of ligand-receptor interaction -- 11.Important LINUX commands -- Literature -- Appendix -- Index.
520			_aG protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is - in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book Modelling of GPCRs a practical handbook is focussed into a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in GPCR modelling, but also addresses the advanced GPCR modeller: On the one hand, the book introduces principles of GPCR modelling, including extensive examples. On the other hand, detailed outlooks onto advanced GPCR modelling techniques are presented. Furthermore, the book includes important data, like information about crystal structures in a summarized manner or amino acid sequences, which are essential for GPCR modelling in general. Due to an increase in efficacy and data handling most modellers use LINUX as operating system. To address this, a summary of most important LINUX commands with examples is presented within the book.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aProteínas G _0comprobar BNE19930003755 _2embne _9147588
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
650		7	_aBioquímica _0comprobar BNE19900962333 _2embne _9138639
700	1		_aWittmann, Hans-Joachim _0nb2012023928 _948465
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-4596-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9789400745964
907			_a.b12823570 _b19-10-17 _c01-10-14
998			_am _a_alco _a_vill _b18-10-17 _cm _dz _ei _feng _gne _h0
945			_aQP552.G16 S77 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11552785 _z06-04-17
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