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008			120726s2013 ne a s 001 0 eng d
020			_a9789400745902
024	7		_a10.1007/978-94-007-4590-2 _2doi
040			_aES-MaUEC
050		4	_aRC267 _b.D53 2013 EB
082	0	4	_a610
245	0	0	_aDNA Repair of Cancer Stem Cells _cedited by Lesley A Mathews, Stephanie M Cabarcas, Elaine M. Hurt
264		1	_aDordrecht, Netherlands _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VIII, 180 p.) :
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface. -1 Introduction to Cancer stem cells.-2 DNA Repair Pathways and Mechanisms.-3 Resistance and DNA repair mechanisms of cancer stem cells: Potential molecular targets for therapy.-4 DNA Repair in Normal Stem Cells.-5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells.-6 DNA Repair Mechanisms in Breast Cancer Stem Cells.7 DNA Repair Mechanisms in other Cancer Stem Cell models -- 8 Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair.-9 Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for new therapeutics -- 10 The Future of DNA Repair and Cancer Stem Cells. Index.
520	3		_aThe existence of cancer stem cells (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
650		7	_aCélulas cancerosas _9146156 _0comprobar BNE19922988962 _2embne
650		7	_aOncología _0comprobar BNE19900969554 _2embne _9139207
700	1		_aMathews, Lesley A. _0nb2012024189 _eeditor literario _948439
700	1		_aCabarcas, Stephanie M. _0nb2012024167 _eeditor literario _948440
700	1		_aHurt, Elaine M. _0nb2012024140 _eeditor literario _948441
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-4590-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9789400745902
907			_a.b12823569 _b18-10-17 _c01-10-14
998			_am _a_alco _a_vill _b18-10-17 _cm _dz _ei _feng _gne _h0
945			_aRC267 .D53 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11552773 _z06-04-17
999			_c76738 _d76738 _x1